Summary

Description

Advanced Liquid Logic proposes to develop a very capable analyzer based on its digital microfluidic technology. Such an analyzer would be:  Capable of both simple and complex biological assays  Small, lightweight, power efficient, and easy to operate  Fully programmable and remotely reprogrammable Under NIH funding we have demonstrated clinical chemistry blood diagnostic testing on our lab-on-a-chip platform. Our vision is to develop a portable diagnostic analyzer that performs the same tests as central lab-based analytical equipment with even broader functionality by integrating hematology, pathology, molecular diagnostics, cytology, microbiology, and serology onto the same platform. These diverse tests would be multiplexed to use the same very small body fluid or solid sample. We believe that digital microfluidics is uniquely capable of meeting NASA's requirements because:  We will be able to address a larger breadth of tests than conventional microfluidics on even smaller sample volumes  Our technology miniaturizes both the assay and the associated equipment  Our droplet-based technology provides positive control of each droplet  Our lab-on-a-chip can be designed for multiple uses, reducing or eliminating the need for disposable components  Our platform could be integrated with implanted or automated minimally invasive sample extraction techniques