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Mussel Watch is the longest running continuous chemical contaminant monitoring program in U.S. coastal and Great Lakes waters and was created in response to concerns over environmental quality of the Nation's coastal and estuarine ecosystems. The Program analyzes chemical and biological contaminant trends in sediment and bivalve tissue collected at over 300 coastal sites from 1986 to present. Parameters monitored include over 150 organic and inorganic contaminants, in sediment and bivalve tissue and bivalve histology; and Clostridium perfringens (pathogen) concentrations. Some of the chemicals regularly quantified include: PAHs, PCBs, chlorinated pesticides including DDT and its metabolites, TBT and its metabolites, major andtrace elements. In addition to the aforementioned legacy contaminants, new contaminants of Emerging Concern (CECs) such as flame retardant polybrominated biphnyl ethers (PBDEs) and pharmaceutics are being analyzed.