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Abstract: Beginning in late 1979, the Alabama Coastal Area Board (CAB) funded a series of baseline surveys on the coastal resources of Alabama, from which they could develop a monitoring program to observe any significant changes in the resources over time. Eight stations within Mobile Bay were sampled monthly from April 1980 to April 1981. Data collected included samples for benthic fauna, pelagic fauna, sediment particle size, total organic carbon, foraminifera, zooplankton, phytoplankton, chlorophyll, turbidity, river flow, and hydrographic parameters. The subset of data presented here are for sediment particle size, total organic carbon, and foraminifera. Data are available from April 1980 to April 1981 for eight stations (14 sampling trips), and one station until August 1981 (4 additional trips). Purpose: To provide benchmark data to the Alabama Coastal Area Board (CAB) for distribution, abundance, and seasonality of benthic infauna, phytoplankton, zooplankton, foraminifera, epifaunal invertebrates and fishes. CAB became part of the Alabama Department of Environmental Management (ADEM) in 1982, and ADEM became part of the Alabama Department of Conservation and Natural Resources (ADCNR) in 2000.