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Protein Colloidal Aggregation Project

Summary

Type of release
a one-off release of a single dataset

Data Licence
Not Applicable

Content Licence
Creative Commons CCZero

Verification
automatically awarded

Release Date
9 April 2015
Modified Date
8 July 2015
Publishers
National Aeronautics and Space Administration
Keywords
completed, kennedy-space-center, project
Identifier
protein-colloidal-aggregation-project
Landing Page
http://techport.nasa.gov/view/11009
Maintainers
John Falker jfalker@nasa.gov
Language
en-US

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Description

<p>The goal of the Protein Colloidal Aggregation project is to understand the underlying cause of several major diseases, including Alzheimer’s, Parkinson’s, and chronic traumatic encephalopathy. These diseases all occur when protein molecules undergo a peculiar and irreversible process in which they aggregate to form tiny fibers of a unique material called amyloid, which the body cannot remove. Despite enormous investment in research, the fundamental physiochemical mechanism of these diseases remains poorly understood. </p><p>Based on initial studies using atomic force microscopy (AFM), we theorized that the aggregation of proteins in these diseases is driven instead by colloidal interactions, the same forces that govern the behavior of nanoscale particles in the colloidal suspensions we encounter every day, such as paint, milk, and clouds.</p><p>Our theory is being validated by the evidence. For many years, NASA has been heavily involved in research into the structure of proteins and their assembly into crystals, and in studying the colloidal interactions and aggregation of nanoscale particles. To date, however, NASA’s colloid research has involved only nonbiological materials. But now we are bridging these two fields by studying the colloidal aggregation of proteins.</p>


General Information


Legal Information

This dataset has been created by US Government which means it is required to be in the public domain. However US copyright law only allows open access by US citizens, we have assumed the data is equivalently licensed as CC0 for the rest of the world as this is in the spirit of the US Government’s Open Data policy.
  • The rights statement is at

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  • Outside the US, this data is available under

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  • The content is available under

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  • This data contains

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Practical Information

  • The data appears in this collection

    http://catalog.data.gov/organization/nasa-gov Do you think this data is incorrect? Let us know

  • The accuracy or relevance of this data will

    go out of date but it is timestamped Do you think this data is incorrect? Let us know

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Technical Information

  • This data is published at

    http://techport.nasa.gov/xml-api/11009 Do you think this data is incorrect? Let us know

  • This data is

    machine-readable Do you think this data is incorrect? Let us know

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  • Find out how to contact someone about this data at

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